SETBP1Strong Team & the Million Dollar Bike Ride

SETBP1 Society and the University of Pennsylvania Orphan Disease Center invite you to participate in the Million Dollar Bike Ride. This annual festival brings together rare disease families, friends and supporters to raise funds for rare disease research and to spread awareness of rare disease. This year’s event will be in person; however, there will be an option to fundraise and ride virtually. The event will take place in Philadelphia, PA on Saturday, June 13th. SETBP1 Society is thrilled to have a team, SETBP1Strong, in this event for the 8th time!

The Million Dollar Bike Ride brings together rare disease teams, each representing a specific rare disease. The money raised by each team funds one or more research grants to study that specific disease. The Million Dollar Bike Ride brings over 750 cyclists and volunteers to Penn’s campus to ride either 10, 30, 52, or 70 miles starting in the city, and ranging across the Greater Philadelphia region. In twelve years, the MDBR’s 30+ teams have raised over $23 million to fund research grants on the diseases they represent. The ODC ensures that 100% of the funds raised goes towards these pilot grants! After the event, grant applications will be open to the international scientific community — scientists from around the world will be eligible to apply.

This is a unique opportunity for the SETBP1 community to work together. It is also an extraordinary opportunity to join with other rare disease patients and organizations.

Our goal again for this year is to raise $60,000 for SETBP1 haploinsufficiency disorder research.

Our SETBP1Strong Team will also need at least 15 in-person riders and/or volunteers! Registered riders need to be 16+ years old to ride or 18+ years old to volunteer at the event!

The SETBP1 Society has sponsored the SETBP1Strong team for the past 8 years. Check out the SETBP1-related research projects funded through the Million Dollar Bike Rides.

DONATE NOW
Join Our Team

Biker riding in the MDBR

Event Details

WHEN: Saturday, June 13th, 2026
WHERE: Philadelphia, PA
START: 7:00am
You can ride in-person or virtually so you can show your support and ride anywhere you choose.
NOTE: 100% of fundraising will go towards SETBP1 research!

We look forward to seeing you in Philly!

How to Join our Team

Options Pick your preferred participation option:

FAQs

Q: Where can we stay in Philadelphia for the MDBR?
A: The Orphan Disease Center has reserved some hotel rooms at a discounted rate for the event. The details will be available soon at https://www.milliondollarbikeride.org/accommodations.
Q: I want to help out at the event but I do not want to ride a bike. How else can I participate?
A: Great question. You have a couple of options. You can register and walk the 1 mile fun walk, which is a great way to participate with your SETBP1 Bee. You can alternatively volunteer. You can learn more about registering as a volunteer (ensure to select that you are volunteering for the SETBP1Strong team) and what options are available at https://www.milliondollarbikeride.org/volunteer.
Q: Who all attends the Million Dollar Bike Ride (i.e., families, bike enthusiasts, locals)?
A: We have had whole SETBP1 families attend. We have had families attend with grandparents, aunts, and uncles. We have had SETBP1 parents only attend. We have had supporters who are family friends attend. We also have some families where some members volunteer, some bike ride and some walk. Please make sure to register everyone attending HERE. Anyone and everyone are welcome!
Q: I want to ride in the MDBR but I will not have a bike with me, what do I do?
A: You can reserve a bike for the event. You can learn more about this option at https://www.milliondollarbikeride.org/bike-rental.
Q: How many miles do I need to ride for the event?
A: There are several route options provided so you can ride a casual ride through town along the river or you can ride a more challenging ride. The routes and maps are available at https://www.milliondollarbikeride.org/routes-and-maps.
Q: I have more questions, where can I find out more about the Million Dollar Bike Ride?
A: The Orphan Disease Center at the University of Pennsylvania hosts the event and you can learn more at their website at https://www.milliondollarbikeride.org.

Detailed Participation Information

Cyclist with Fundraising: Registration is easy! The registration fee is $30 and requires a minimum fundraising commitment of $250. It is expected that the minimum is met by June 13th.
  1. Step 1: Register! Get a free SETBP1Strong Team t-shirt, MDBR t-shirt & MDBR jersey (early registration only for jersey)!
  2. Step 2: Set up Fundraising Page - You can view a sample page at https://charity.pledgeit.org/f/dRS3rNK2l7
  3. Step 3: Share your Fundraising Page!
Walker with Fundraising: Registration is easy! The registration fee is $15 and we welcome you to help fundraise. Walkers ages 16+ count towards our SETBP1Strong in-person participant count.
  1. Step 1: Register! Get a free SETBP1Strong Team t-shirt if you commit to raising $250 or more!
  2. Step 2: Set up Fundraising Page - You can view a sample page at https://charity.pledgeit.org/f/dRS3rNK2l7
  3. Step 3: Share your Fundraising Page!
Virtual Rider With Fundraising: No Registration Fee, but a donation of $10 or more is requested.
  1. Step 1: Register! Get a free SETBP1Strong Team t-shirt if you commit to raising $250 or more!
  2. Step 2: Set up Fundraising Page - You can view a sample page at https://charity.pledgeit.org/f/dRS3rNK2l7
  3. Step 3: Share your Fundraising Page!
In-Person Volunteer with Fundraising: No registration fee. Volunteers ages 18+ count towards our SETBP1Strong in-person participant count.
  1. Step 1: Register! Get a free SETBP1Strong Team t-shirt if you commit to raising $250 or more!
  2. Step 2: Set up Fundraising Page if you plan to fundraise - You can view a sample page at https://charity.pledgeit.org/f/dRS3rNK2l7
  3. Step 3: Share your Fundraising Page!
Cyclist without Fundraising: Early Bird Fee: $65 By June 8th Fee: $85 Day of Ride: $125
  1. Step 1: Register!